AMERICAN MEDICAL ASSOCIATION 1999
Osteoarthritis is not simply a degenerative disorder. Rather, it is a complex derangement of articular surfaces that involves the loss of normal collagen architecture followed by an attempt by chondrocytes to produce replacement cartilage. The replacement surface is less resistant to wear than the original. Over time, fullthickness cartilage loss may develop on the articular surfaces. Symptoms of osteoarthritis include joint pain, typically worse with use and eased with rest, and joint stiffness after nonuse. The pain can become persistent.