2018 Bone & Joint
Biological approaches to treat orthopaedic injuries seek to improve clinical outcomes by promoting tissue regeneration and healing. These approaches can be used in isolation or as an augment to surgical interventions. They include, but are not limited to, preparations of growth factors, autologous blood products, and cells. Despite considerable research effort, the majority of biological approaches have not yet achieved a sufficient evidence base to war- rant widespread clinical application, and inappropriate use is a growing problem. This article aims to outline concepts underlying some of the key biological approaches, namely growth factors, autologous blood products (including platelet-rich plasma or PRP), and mesenchymal stem/stromal cells (MSCs), highlighting current challenges that limit clinical translation and application.
Download Full Article Biologics in orthopaedics concepts and controversies