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Characterization of Growth Factors, Cytokines, and Chemokines in Bone Marrow Concentrate and Platelet-Rich Plasma: A Prospective Analysis


Background:

Platelet-rich plasma (PRP) and bone marrow concentrate (BMC) are orthobiologic therapies with numerous growth factors and other bioactive molecules. Before the clinical utility of PRP and BMC is optimized as a combined therapy or monotherapy, an improved understanding of the components and respective concentrations is necessary.

Purpose:

To prospectively measure and compare anabolic, anti-inflammatory, and proinflammatory […]

Characterization of Growth Factors, Cytokines, and Chemokines in Bone Marrow Concentrate and Platelet-Rich Plasma: A Prospective Analysis

Platelet-Rich Plasma for Patellar Tendinopathy: A Randomized Controlled Trial of Leukocyte-Rich PRP or Leukocyte-Poor PRP Versus Saline


Background:

A small number of randomized controlled trials have found ultrasound-guided injection of platelet-rich plasma (PRP) to be no more effective than saline for several tendinopathies; limited information exists for patellar tendinopathy. In addition, different PRP formulations that produce varying concentrations of leukocytes have not been directly compared for patellar tendinopathy.

Purpose/Hypothesis:

To determine if a single […]

Platelet-Rich Plasma for Patellar Tendinopathy: A Randomized Controlled Trial of Leukocyte-Rich PRP or Leukocyte-Poor PRP Versus Saline

The Influence of Naproxen on Biological Factors in Leukocyte-Rich Platelet-Rich Plasma: A Prospective Comparative Study


2019 Arthroscopy Techniques

Musculoskeletal (MSK) disorders are one of the leading causes of physical disability worldwide, and the treatment and prevention of MSK disorders can alleviate substantial indirect and direct health care costs.1 Leukocyte-rich platelet-rich plasma (LR-PRP) has been used to treat the injured MSK system by initiating the healing and regeneration processes. LR-PRP is […]

The Influence of Naproxen on Biological Factors in Leukocyte-Rich Platelet-Rich Plasma: A Prospective Comparative Study

Biologics in Orthopaedics Concepts and Controversies


2018 Bone & Joint

Biological approaches to treat orthopaedic injuries seek to improve clinical outcomes by promoting tissue regeneration and healing. These approaches can be used in isolation or as an augment to surgical interventions. They include, but are not limited to, preparations of growth factors, autologous blood products, and cells. Despite considerable research effort, […]

Biologics in Orthopaedics Concepts and Controversies

Reporting of Mesenchymal Stem Cell Preparation Protocols and Composition


Background:

Mesenchymal stem cells (MSCs) are increasingly being used in the treatment of a wide variety of sports-related conditions. Despite this enthusiasm, the biological properties of MSCs and their effects on musculoskeletal tissue healing remain poorly understood. MSC-based strategies encompass cell populations with heterogeneous phenotypes isolated from multiple tissues and using different methods. Therefore, comprehensive […]

Reporting of Mesenchymal Stem Cell Preparation Protocols and Composition

Reporting of Mesenchymal Stem Cell Preparation Protocols and Composition

The ability of mesenchymal stem cells (MSCs) to differentiate into multiple musculoskeletal cell types, release proregenerative growth factors, and inhibit local immune responses holds great promise for musculoskeletal tissue engineering and the treatment of sports-related pathologic conditions. Promising in vitro data have further fueled enthusiasm for MSC-based therapies, and […]

Reporting of Mesenchymal Stem Cell Preparation Protocols and Composition

Use of Platelet-Rich Plasma Immediately After an Injury Did Not Improve Ligament Healing, and Increasing Platelet Concentrations Was Detrimental in an In Vivo Animal Model

Background: Limited information in basic science and clinical trials exists to determine if ligament healing may be accelerated with the use of biological adjuvants, such as platelet-rich plasma (PRP). However, there has been widespread acceptance of PRP for use in clinical practice, despite an inadequate understanding of its biological […]

Use of Platelet-Rich Plasma Immediately After an Injury Did Not Improve Ligament Healing, and Increasing Platelet Concentrations Was Detrimental in an In Vivo Animal Model

A Call for Standardization in Platelet-Rich Plasma Preparation Protocols and Composition Reporting


2017 The Journal of Bone and Joint Surgery

Background: Platelet-rich plasma (PRP) is a blood-derived preparation whose use has grown exponentially in orthopaedic practice. However, there remains an unclear understanding of the biological properties and effects of PRP on musculoskeletal healing. Heterogeneous processing methods, unstandardized nomenclature, and ambiguous classifications make comparison among studies challenging. A comprehensive […]

A Call for Standardization in Platelet-Rich Plasma Preparation Protocols and Composition Reporting

Minimum Information for Studies Evaluating Biologics in Orthopaedics (MIBO): Platelet-Rich Plasma and Mesenchymal Stem Cells

It is not yet clear whether current and emerging biologic strategies to treat musculoskeletal injuries will provide tangible benefits to patients . Platelet-rich plasma (PRP) is used widely despite a lack of evidence supporting its efficacy. Enthusiasm for mesenchymal stem cell (MSC)-based therapies is reflected by the prodigious number […]

Minimum Information for Studies Evaluating Biologics in Orthopaedics (MIBO): Platelet-Rich Plasma and Mesenchymal Stem Cells

Evidence for the use of cell-based therapy for the treatment of osteonecrosis of the femoral head: A Systematic Review of the literature

Cell-therapy has been promoted among the therapeutic arsenal that can aid in 6 bone formation and remodeling, in early stages of osteonecrosis of the femoral head (ONFH). The purpose of this systematic review was to assess the evidence supporting the: (1)clinical efficacy; (2)structural modifying effect; as evaluated radiographically (3) revision rates; and (4)safety of […]

Evidence for the use of cell-based therapy for the treatment of osteonecrosis of the femoral head: A Systematic Review of the literature
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